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It is interesting to note that all Zn 2+ containing combinations including Zn 2+ alone also exhibited positive regulatory effect on the 5 genes expression, while Cu 2+ and Qu alone displayed a much weaker regulatory ability indicating Zn 2+ is the key factor for the protection of DHT-injured HHDPCs and Cu 2+ and Qu only contribute to the synergetic effect by combining with Zn 2+ ions